Traditional Caco-2 monolayer models fall short when predicting human-relevant intestinal toxicity, particularly for inflammation-driven responses like diarrhea. VivoSim’s NAMkind™ Intestine Model offers a breakthrough solution—combining physiological relevance with predictive power. Built on a 3D Transwell platform, the NAMkind™ Intestine Model incorporates both epithelial and stromal cells, enabling a more accurate recreation of native intestinal tissue and function. This advanced model allows for best-in-class diarrhea and inflammatory toxicity prediction, capturing key cytokine signaling that traditional models miss.
With integrated assays to measure epithelial barrier integrity (TEER) and differentiate between the viability of epithelial and stromal compartments, the NAMkind™ Intestine Model delivers a detailed and dynamic view of gut health under drug exposure, empowering researchers to make safer, more informed decisions earlier in development.
INTESTINAL TOXICITY TESTING FROM
OUR NAMkind INTESTINE MODEL
Fast. Cost-effective. Predictive.
1. Epithelial Cell Layer
2. Stromal Cells
- Endothelial Cells
- Smooth Muscle Cells
- Transwell Insert
3. Permeable Membrane
4. Transwell Insert
Publications
October, 2025
Bioprinted 3D Primary Human Intestinal Tissues Model Aspects of Native Physiology and ADME/Tox Functions
Madden LR, Nguyen TV, Garcia‑Mojica S, et al. iScience. 2018;2:156–167. doi: 10.1016/j.isci.2018.03.015
Read more »October, 2025
Development of a Multicellular 3D Intestinal Model Using Human Primary Cells to Identify Novel IBD Therapies
Gervacio S, Dudum R, Aidnick H, et al. Digestive Disease Week 2025, Abstract No. Tu2035
Read more »October, 2025
Identification of JAK Inhibitors as Potential Therapeutics for Inflammatory Bowel Disease Using Human Primary Cell 3D Models of Crohn’s Disease and Ulcerative Colitis
Dudum R, Payton O, Toohey C, et al. Digestive Disease Week 2025, Abstract No. Tu2040
Read more »