Intestine Toxicology Services Overview
Validated 3-D models, bespoke analytics, actionable output
Drug-induced gastrointestinal (GI) toxicity and AEs/SEs, particularly diarrhea, are a leading cause of clinical product development attrition. The NAMkind™ Intestine Model from VivoSim offers a robust, human-relevant solution, combining advanced Transwell-based technology with expert scientific support to help you detect and mitigate GI risk early. Unlike traditional static in vitro screens, our full-service platform provides comprehensive insight through barrier function testing (TEER), cell viability assays (ATP, Alamar Blue), and histological analysis for structural damage. Share your compounds and key questions, and within four weeks, you will receive detailed, clinically relevant results.
Built with human epithelial and key stromal cells such as endothelial, smooth muscle cells, and fibroblasts, the model replicates the intestinal barrier’s complexity to move beyond single-layer cultures, enabling more predictive and translational assessments of drug-induced toxicity. Our scientists collaborate directly with your team, interpreting results, contextualizing risk, and providing strategic recommendations aligned with your development milestones. Whether you are performing early compound screening, validating clinical findings, or probing structure-toxicity relationships, the NAMkind™ Intestine Model delivers clarity and confidence.
Intestinal Toxicity Testing From Our Namkind™ Intestine Model
Fast. Functional. Predictive.
We assess intestinal toxicity with:
Epithelial Barrier Integrity – TEER
Cell Viability – ATP Content
Cellular Redox Status – AlamarBlue Assay
Histological Assessment
How the service works
Our gastrointestinal toxicity service begins as soon as your compound arrives. We establish NAMkind™ Intestine Transwell cultures containing epithelial, endothelial, smooth-muscle, and fibroblast layers, apply a seven-day exposure protocol at four concentrations, and assess barrier integrity, cell health, and redox balance.
Standard service timeline
Day -3 Seeding Liver Model
Day 0 1st Dosing
Weeks 1-3 2-7th Repeat Dosing
Week 3 Experimentation Completed
Weeks 3-4 Data Analysis
Week 4 Data Output
Why Our 3D NAMkind™ Intestine Model for Toxicology
Built for predictive intestinal toxicology, our model combines multicellular complexity with robust functional assays to support high-throughput screening and mechanistic insight.
Maintain viable cultures for 21 days to support chronic and delayed toxicity evaluation
Reduce costs by combining multiple endpoints into a single, scalable transwell assay
Measure barrier function using TEER and redox viability assays for clear epithelial health insights
Predict inflammation and diarrhea with higher accuracy using multicellular intestinal model
